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  1. Cell therapy for scleroderma involves several approaches123:
    1. Haematopoietic stem cell transplantation: A treatment for moderate to severe early scleroderma.
    2. Novel cell therapies: Investigated as potential disease-modifying options.
    3. Autologous hematopoietic stem cell transplants: Involves collecting the participant’s blood-forming stem cells and killing bone marrow cells using radiation therapy or chemotherapy.
    4. Stem cells may help: Modulate the immune system, promote tissue repair, reduce fibrosis, and enhance quality of life.
    Learn more:
    • Haematopoietic stem cell transplantation is a treatment for moderate to severe early scleroderma.
    • Novel cell therapies are being investigated as potential disease-modifying options for the treatment of scleroderma.

    Improving outcomes in scleroderma: rece…

    academic.oup.com/rheumatology/article/62/6/2060/…
    Researchers have been studying autologous hematopoietic stem cell transplants for treating scleroderma. In this approach, doctors first collect the participant’s blood-forming stem cells. Next, cells in the bone marrow are killed using either radiation therapy or chemotherapy, or a combination.

    Stem cell transplant helps people with se…

    www.nih.gov/news-events/nih-research-matters/ste…

    Stem Cell Treatments for Scleroderma

    • Modulating the Immune System Scleroderma involves an overactive immune response that leads to tissue damage. ...

    Stem Cell Treatments for Scleroderma | S…

    www.stemcellcouncil.com/treatments/stem-cell-trea…
  2. People also ask
    How do doctors treat scleroderma?
    To manage symptoms, doctors often prescribe cyclophosphamide, an immune-suppressing drug. Researchers have been studying autologous hematopoietic stem cell transplants for treating scleroderma. In this approach, doctors first collect the participant’s blood-forming stem cells.

    Stem cell transplant helps people with severe scleroderma

    nih.gov
    Can hematopoietic stem cell transplantation treat scleroderma?
    Haematopoietic stem cell transplantation is a treatment for moderate to severe early scleroderma. Novel cell therapies are being investigated as potential disease-modifying options for the treatment of scleroderma. Self-tolerance may be restored with enriched populations of mesenchymal, dendritic or facilitating cells.

    Improving outcomes in scleroderma: recent progress of cell

    academic.oup.com
    Can stem cells help people with severe scleroderma?
    A physician consults with a woman. Daniel Sone, NCI New clinical trial findings show that a therapeutic regimen involving transplantation of a person’s own blood-forming stem cells can improve survival and quality of life for people with severe scleroderma, a life-threatening autoimmune disease.

    Stem cell transplant for severe scleroderma improves

    nih.gov
    Can cutaneous scleroderma be cured?
    The more severe form of the disease, diffuse cutaneous scleroderma (dcSSc), has no cure and limited treatment options. Haematopoietic stem cell transplantation has emerged as a potentially disease-modifying treatment but faces challenges such as toxicity associated with fully myeloablative conditioning and recurrence of autoimmunity.

    Improving outcomes in scleroderma: recent progress of cell

    academic.oup.com
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  3. Studies of cell therapy on scleroderma
    National Center for Biotechnology Information
    Cellular-Based Therapies in Systemic Sclerosis: From Hematopoietic Stem Cell Transplant to Innovative Approaches
    Systemic sclerosis (SSc) is a systemic disease characterized by autoimmune responses, vasculopathy and tissue fibrosis. The pathogenic mechanisms involve a wide range of cells and soluble factors. The complexity of interactions leads to heterogeneous
    Author: Elisabetta Xue…
    Published: 2022/11
    Publication: Cells. 202…
    PubMed
    Improving outcomes in scleroderma: recent progress of cell-based therapies
    Scleroderma is a rare, potentially fatal, clinically heterogeneous, systemic autoimmune connective tissue disorder that is characterized by progressive fibrosis of the skin and visceral organs, vasculopathy and immune dysregulation. The more severe form
    Author: Dinesh Khanna
    Published: 2023/06/01
    Keywords: cell transpl…
    PubMed
    Autologous stem cell transplantation in scleroderma
    Patients with severe rapidly progressive systemic sclerosis (SSc) have a poor prognosis. Standard immunosuppressive therapies may have modest effects on stabilizing disease, but they fail to improve overall survival. Hematopoietic stem cell transplant
    Author: Dominique Farge
    Published: 2021/4
    Keywords: National In…
    National Center for Biotechnology Information
    Emerging treatments for scleroderma/systemic sclerosis
    Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs and has significant clinical sequelae. Management of SSc cutaneous disease remains challenging and often is driven by extracutaneous
    Author: Jane L Zhu, S…
    Published: 2021
    Publication: Fac Rev. …
    PubMed
    Stem cell therapy in scleroderma
    Scleroderma has a high mortality rate, especially in patients with early diffuse disease and poor prognostic features (such as high skin scores and internal organ involvement). In addition, there is no proven therapy for this disease. Finally, scleroderma
    Author: Yolanda Brau…
    Published: 2002/11
    Keywords: National In…
  4. Oxford Academic
    https://academic.oup.com/rheumatology/article/62/6/2060/6820922

    Improving outcomes in scleroderma: recent progress of cell-based …

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    • National Institutes of Health (NIH)
      https://www.nih.gov/news-events/nih-res…

      Stem cell transplant helps people with severe …

      WebJan 23, 2018 · Researchers have been studying autologous hematopoietic stem cell transplants for treating scleroderma. In this approach, doctors …

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        Stem cell therapy in scleroderma - PubMed
        pubmed.ncbi.nlm.nih.gov
        Myeloablative Autologous Stem-Cell Transplantation for …
        nejm.org
        Recommended to you based on what's popular • Feedback
      • Nature
        https://www.nature.com/articles/s41420-022-01264-2

        Mesenchymal stem cells alleviate systemic sclerosis by ... - Nature

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        Mesenchymal Stem Cell-Based Therapy as a New Approach …
        pubmed.ncbi.nlm.nih.gov
        CCL2 and CXCL12 Derived from Mesenchymal Stromal …
        pubmed.ncbi.nlm.nih.gov
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      • The New England Journal of Medicine
        https://www.nejm.org/doi/full/10.1056/NEJM…

        Myeloablative Autologous Stem-Cell Transplantation …

        WebJan 3, 2018 · Myeloablative autologous hematopoietic stem-cell transplantation achieved long-term benefits in patients with scleroderma, including improved event-free and overall survival, at a cost of...

        Tags:
        Severe Scleroderma
        Publish Year:2018
      • National Center for Biotechnology Information
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658618

        Cellular-Based Therapies in Systemic Sclerosis: From …

        Tags:
        Systemic Sclerosis
        Cells. 2022 Nov; 11(21): 3346.
        Published:2022/11
      • PubMed
        https://pubmed.ncbi.nlm.nih.gov/36355455

        Improving outcomes in scleroderma: recent progress of cell-based …

        Tags:
        Stem Cell Research
        Mesenchymal Stem Cells
        Scleroderma Trials
      • National Institutes of Health (NIH)
        https://www.nih.gov/news-events/news-releases/stem-cell-transplant...

        Stem cell transplant for severe scleroderma improves survival, …

        Tags:
        Severe Scleroderma
        Stem Cells
        Stem Cell Transplant Scleroderma
      • PubMed
        https://pubmed.ncbi.nlm.nih.gov/33548374

        Autologous stem cell transplantation in scleroderma - PubMed

        Tags:
        Stem Cell Research
        Stem Cells
        Stem Cell Transplant Scleroderma
      • Nature
        https://www.nature.com/articles/s41584-023-00909-5

        State-of-the-art evidence in the treatment of systemic sclerosis