Neofibularia nolitangere, commonly known as the touch-me-not sponge, is a species of sea sponge in the family Biemnidae. It is found in shallow waters in the Western Atlantic Ocean and the Caribbean Sea.

Neofibularia nolitangere (Duchassaing 1864) A large, irregular and lumpy sponge, which is brown to reddish brown. Colonies are composed of several connected, thick walled cylinders or mounds, each with large exhalent openings. The outer surface is lumpy but smooth.

The Touch-Me-Not Sponge, scientifically known as Neofibularia nolitangere, is a fascinating marine invertebrate found in the warm waters of the Caribbean Sea. This sponge is known for its unique chemical defense mechanism, which releases toxins when touched, deterring predators and earning its common name.