Leber congenital amaurosis (LCA) is used for a group of genetic eye conditions that cause blindness or severe vision loss. It is typically congenital or noted within the first six months of life. Even though it is rare, LCA is one of the most common causes of severe sight loss in children.

Leber congenital amaurosis is a collective term applied to multiple recessively inherited conditions with early-onset retinal dystrophy causing infantile or early childhood blindness. There are no established diagnostic criteria. First signs are usually noted before the age of 6 months.

Leber congenital amaurosis (LCA) is a family of congenital retinal dystrophies that results in severe vision loss at an early age. Patients usually present with nystagmus, sluggish or near-absent pupillary responses, severely decreased visual acuity, photophobia, and high hyperopia.