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  1. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386233

    Cyclic Peptides in Pipeline: What Future for These Great Molecules?

  2. American Association of Immunologists
    https://journals.aai.org/.../Plitidepsin-as-an-Immunomodulator-against

    Plitidepsin as an Immunomodulator against Respiratory Viral …

  3. 他の人はこちらも質問
    Is plitidepsin a cyclic depsipeptide?
    Abstract Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities in marine tunicate extracts. ...

    A Semisynthesis Platform for the Efficient Production and Exploration

    onlinelibrary.wiley.com
    Is plitidepsin a dehydrodidemnin?
    Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities in marine tunicate extracts. Herein, we introduce a new approach that integrates microbial and chemical synthesis to generate plitidepsin and its analogues.

    A Semisynthesis Platform for the Efficient Production and Exploration

    onlinelibrary.wiley.com
    Is plitidepsin a sustainable natural product?
    This sustainable approach holds potential for investigating other marine natural products. Plitidepsin (or dehydrodidemnin B), an approved anticancer drug, belongs to the didemnin family of cyclic depsipeptides, which are found in limited quantities in marine tunicate extracts.

    A Semisynthesis Platform for the Efficient Production and Exploration

    onlinelibrary.wiley.com
    What is plitidepsin (pm90001)?
    Plitidepsin (PM90001) is a marine-derived depsipeptide that was approved in Australia for the treatment of multiple myeloma [ 170 ]. The Plitidepsin discovery process started with its isolation from a Mediterranean marine tunicate ( Aplidium albicans) and later was fully synthesized [ 170 ].

    Cyclic Peptides in Pipeline: What Future for These Great Molecules?

    ncbi.nlm.nih.gov
    Who has submitted a patent on plitidepsin?
    H.Z., M.C., W.S. and X.T. have submitted a patent on the production of plitidepsin and its derivatives using the described methods (patent number: CN117304255A). The remaining authors declare no conflict of interest.

    A Semisynthesis Platform for the Efficient Production and Exploration

    onlinelibrary.wiley.com
    Can plitidepsin treat multiple myeloma?
    Notably, dehydrodidemnin B (also called plitidepsin), a close analogue of didemnin B featuring a reduced side chain, was successfully approved as a drug for treating multiple myeloma in Australia in 2018. Recently, plitidepsin has gained considerable attention as a potential anti-COVID-19 agent in clinical trials. [ 2]

    Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug

    onlinelibrary.wiley.com
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  4. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1002/anie.202318784

    A Semisynthesis Platform for the Efficient Production and …

  5. Oxford Academic
    https://academic.oup.com/bib/article/25/3/bbae190/7659283

    CyclicPepedia: a knowledge base of natural and synthetic cyclic ...

  6. Nature
    https://www.nature.com/articles/s41579-024-01036-y

    COVID-19 drug discovery and treatment options - Nature

  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/37481109

    Outcomes and clinical characteristics of the compassionate use of ...

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11018982

    Review of COVID-19 Therapeutics by Mechanism: From Discovery …

  9. Taylor & Francis Online
    https://www.tandfonline.com/doi/full/10.1080/23744235.2024.2351043

    Full article: Outcomes and clinical characteristics of the ...

  10. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1002/advs.202306044

    Unveiling a CAAX Protease‐Like Protein Involved in Didemnin …

  11. Europe PMC
    https://europepmc.org/article/MED/38416036

    Plitidepsin as an Immunomodulator against Respiratory Viral …

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