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    • Haematopoietic stem cell transplantation is a treatment for moderate to severe early scleroderma.
    • Novel cell therapies are being investigated as potential disease-modifying options for the treatment of scleroderma.
    • Self-tolerance may be restored with enriched populations of mesenchymal, dendritic or facilitating cells.

    Improving outcomes in scleroderma: recent progress of cell-base…

    academic.oup.com/rheumatology/article/62/6/2060/6820922
    academic.oup.com/rheumatology/article/62/6/2060/6820922
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    How is scleroderma treated?
    The current treatment regimens for scleroderma primarily target inflammation, fibrosis, and vascular dysfunction and include systemic and topical treatments. Systemic therapies consist of glucocorticoids, immunosuppressants, biological agents, small molecule compounds, and hematopoietic stem cell transplantation (HSCT).

    Clinical Treatment Options in Scleroderma: Recommendations and

    link.springer.com
    Can stem cells help people with severe scleroderma?
    A physician consults with a woman. Daniel Sone, NCI New clinical trial findings show that a therapeutic regimen involving transplantation of a person’s own blood-forming stem cells can improve survival and quality of life for people with severe scleroderma, a life-threatening autoimmune disease.

    Stem cell transplant for severe scleroderma improves

    nih.gov
    Can hematopoietic stem cell transplantation treat scleroderma?
    Haematopoietic stem cell transplantation is a treatment for moderate to severe early scleroderma. Novel cell therapies are being investigated as potential disease-modifying options for the treatment of scleroderma. Self-tolerance may be restored with enriched populations of mesenchymal, dendritic or facilitating cells.

    Improving outcomes in scleroderma: recent progress of cell

    academic.oup.com
    Can cutaneous scleroderma be cured?
    The more severe form of the disease, diffuse cutaneous scleroderma (dcSSc), has no cure and limited treatment options. Haematopoietic stem cell transplantation has emerged as a potentially disease-modifying treatment but faces challenges such as toxicity associated with fully myeloablative conditioning and recurrence of autoimmunity.

    Improving outcomes in scleroderma: recent progress of cell

    academic.oup.com
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  3. Oxford Academic
    https://academic.oup.com/rheumatology/article/62/6/2060/6820922

    Improving outcomes in scleroderma: recent progress of cell-based …

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    Emerging drugs for the treatment of scleroderma: a …
    pubmed.ncbi.nlm.nih.gov
    Emerging treatments for scleroderma/systemic sclerosis
    pubmed.ncbi.nlm.nih.gov
    Scleroderma | New England Journal of Medicine
    nejm.org
    Scleroderma therapy: clinical overview of current trends …
    link.springer.com
    13 Years in the Making – Immunotherapy for Scleroderma
    med.stanford.edu
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  4. Nature
    https://www.nature.com/articles/s41584-023-00909-5

    State-of-the-art evidence in the treatment of systemic sclerosis

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    An update on targeted therapies in systemic sclerosis …
    pubmed.ncbi.nlm.nih.gov
    New ACR EULAR guidelines for systemic sclerosis …
    researchgate.net
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  6. National Institutes of Health (NIH)
    https://www.nih.gov/news-events/nih-res…

    Stem cell transplant helps people with severe …

    Web23 jan. 2018 · Researchers have been studying autologous hematopoietic stem cell transplants for treating scleroderma. In this approach, doctors …

    • Geschatte leestijd: 4 min.

      Ontdek verder

      Stem cell therapy in scleroderma - PubMed
      pubmed.ncbi.nlm.nih.gov
      Myeloablative Autologous Stem-Cell Transplantation for …
      nejm.org
      Aanbevolen op basis van wat populair is • Feedback
    • National Center for Biotechnology Information
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466985

      Current Advances in the Treatment of Systemic Sclerosis - PMC

      Tags:
      Systemic Sclerosis
      Multiple Sclerosis
      Heather Bukiri, Elizabeth R. Volkmann
    • The New England Journal of Medicine
      https://www.nejm.org/doi/full/10.1056/NEJM…

      Myeloablative Autologous Stem-Cell Transplantation …

      Web3 jan. 2018 · Myeloablative autologous hematopoietic stem-cell transplantation achieved long-term benefits in patients with scleroderma, including improved event-free and overall survival, at a cost of...

      Tags:
      Severe Scleroderma
      Publish Year:2018
    • National Center for Biotechnology Information
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658618

      Cellular-Based Therapies in Systemic Sclerosis: From …

      Tags:
      Systemic Sclerosis
      Cells. 2022 Nov; 11(21): 3346.
      Published:2022/11
    • Springer
      https://link.springer.com/article/10.1007/s12016-020-08831-4

      Clinical Treatment Options in Scleroderma: Recommendations and ...

      Tags:
      Clinical Trials Scleroderma
      Scleroderma Review Article
      Scleroderma Ncbi
    • Springer
      https://link.springer.com/article/10.1007/s12016-021-08892-z

      Mesenchymal Stem Cell–Based Therapy as a New Approach for

      Tags:
      Systemic Sclerosis
      Multiple Sclerosis
      Stem Cell Research
    • Oxford Academic
      https://academic.oup.com/rheumap/article/7/3/rkad101/7429405

      Stem cell-based therapy for systemic sclerosis - Oxford Academic

      Tags:
      Systemic Sclerosis
      Stem Cells
    • National Institutes of Health (NIH)
      https://www.nih.gov/news-events/news-releases/stem-cell-transplant...

      Stem cell transplant for severe scleroderma improves survival, …

      Tags:
      Severe Scleroderma
      Stem Cells
      Stem Cell Transplant