CTLA-4 - Wikipedia, la enciclopedia libre
WEBCTLA-4, acrónimo del inglés Cytotoxic T-Lymphocyte Antigen 4 (antígeno 4 del linfocito T citotóxico) es un receptor proteico situado en la membrana celular de los línfocitos T, una de las principales células encargadas de la inmunidad. La función del linfocito T, se ve inhibida por la estimulación del receptor CTLA-4.
Current understanding of CTLA-4: from mechanism to …
WEBJul 11, 2023 · CTLA-4 is a T-cell co-receptor, also known as CD152. Compared to CD28, CTLA-4 has a superior binding affinity with B7 family molecules, including CD80 and CD86 on antigen-presenting cells (APCs). Although CTLA-4 binds with B7 co-stimulatory receptors, it plays a negative role in the activation of T cells .
Molecular and Cellular Functions of CTLA-4 - PubMed
WEBCTLA-4 is well recognized as a key immune checkpoint and has gained significant momentum as a therapeutic target in the field of autoimmunity and cancer. In this chapter, we describe the role of costimulation in immune response induction as well as the main mechanisms by which CTLA-4 can inhibit this process.
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
WEBAug 8, 2022 · Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and regulates immune homeostasis. Due to the crucial functions of CTLA-4 in T-cell biology, CTLA-4-targeted immunotherapies have been developed for …
CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
WEBMar 22, 2021 · This review will describe the mechanisms of CTLA-4 immune checkpoint inhibition, the role of T reg cells in tumorigenesis, and how anti-CTLA-4 antibodies can provoke an alteration in the expression of CTLA-4 on T reg cells while exerting anti-cancer therapeutic activity.
Anti-CTLA-4 nanobody as a promising approach in cancer
WEBJan 8, 2024 · Cytotoxic T lymphocyte-associated protein-4 (CTLA-4) is an essential immune molecule that plays a vital role in cell cycle modulation, regulation of T cell proliferation, and cytokine...
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell ...
WEBNov 25, 2011 · Key Points. Cytotoxic T lymphocyte antigen 4 (CTLA4) and its homologue CD28 are crucial T cell proteins associated with immune regulation. They share the same ligands, CD80 and CD86,...
CTLA-4: Checkpoints beyond the membrane: Molecular Therapy
WEBJan 17, 2024 · The discovery that the checkpoint receptors CTLA-4 and PD-1 regulate anti-tumor T cell immunity has revolutionized the field of cancer therapy since ipilimumab, a monoclonal antibody (mAb) specific for CTLA-4, was first shown to prolong survival in patients with difficult-to-treat metastatic melanoma over 10 years ago.
Unraveling the role of CTLA-4 variants in acute kidney injury after …
WEB4 days ago · Among these, the variant with the strongest association was located at the cytotoxic T lymphocyte antigen 4 (CTLA-4) gene locus, rs3087243 (chr2: 203874196, G>A,T). This genotype exhibited a significant inverse relationship with AKI risk (beta = -8.19e-2, P = 2e-11), suggesting that reduced activity of the CTLA-4 gene may be linked …
Two CTLA-4 ligands, separate pHates | Nature Immunology
WEBAug 23, 2022 · Nature Immunology - The inhibitory checkpoint molecule CTLA-4 is essential for regulatory T cell function. A new study highlights the differential manner in which CTLA-4 binds CD80 and CD86, which...
Skip to content