Spongian diterpenes are a group of marine natural compounds possessing various biological activities. However, their anticancer activity is still poorly studied and understood. We isolated six spongian diterpenes from the marine sponge Spongionella

Eight 3b,5a,6b-trihydroxysterols [1-8], of which four are new, have been isolated from the sponge Spongionella gracilis and their structures deduced by spectroscopic and chemical evidence.

Marine sponges are found to be a wide source of bioactive compounds with different effects such as anti-inflammatory or anticancer actions among others. Cyclophilin A (Cyp A) is a target protein implicated in the mechanism of action of immunosuppressive