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  1. (Avarol) - 药物靶点:HIV-1 protease_专利_临床_研发

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    The explants glued to the substrate presented a similar bioactivity to the wild specimens, which points to this method as the best culture method for Dysidea avara culture, when obtaining secondary metabolites is attempted.
    Some generalization can be envisaged as for Dysidea avara growth: high growth rates have been recorded with the three methods assayed, but high growth variability has also been recorded among explants cultured under the same method.
    The biomedical potential of Dysidea avara has generated a wide variety of studies about different culture techniques based on this sponge species. Attempts to establish cell cultures of D. avara have also been performed based on both cell suspensions and cell aggregates (primmorphs) [ 13 – 17 ].
    As for explant growth, gluing the explants to horizontal solid substrates such a metallic frame seemed to be the best method to culture Dysidea avara in the sea. At the end of the experiment (ten months) the explants glued to the substrate had the largest final size.