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  1. Monoclonal antibody
    Nucala (mepolizumab) is a monoclonal antibody1234used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES).
    Learn more:
    Nucala is a monoclonal antibody that works by reducing levels of eosinophils (a type of white blood cell).

    Nucala Injection: Uses, Dosage & Side Eff…

    www.drugs.com/nucala.html
    Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES).

    Mepolizumab - Wikipedia

    en.wikipedia.org/wiki/Mepolizumab
    Mepolizumab (Nucala®) What is mepolizumab? Mepolizumab is a monoclonal antibody approved for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA).

    Mepolizumab (Nucala®) : Johns Hopkin…

    www.hopkinsvasculitis.org/vasculitis-treatments/me…

    Nucala (mepolizumab) is an interleukin-5 (IL-5) antagonist monoclonal antibody (IgG1 kappa) indicated for add-on maintenance treatment of patients with severe asthma aged 6 years and older, and with an eosinophilic phenotype; the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA); and the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES)...

    Nucala (Mepolizumab For Injection): Sid…

    www.rxlist.com/nucala-drug.htm
  2. People also ask
    Are monoclonal antibodies safe?
    Given their loss of efficacy, there are currently no monoclonal antibodies that are approved for preventive use. For infected individuals who may develop severe forms, the recommended treatments are antiviral drugs like the nirmatrelvir/ritonavir combination or remdesivir.

    COVID-19: which monoclonal antibodies should be used for vulnerable

    pasteur.fr
    Can a computational redesign of a monoclonal antibody recover efficacy against escape variants?
    Computational redesign of a clinically proven monoclonal antibody shows promise for recovering efficacy against escape variants, especially for antibodies known to complement other monoclonal antibodies as part of a combination antibody drug product 12.

    Computationally restoring the potency of a clinical antibody ... - Nature

    nature.com
    How do monoclonal antibodies work?
    Monoclonal antibodies used to treat infectious diseases recognize a specific part of the microbe – the antigen – and bind to it. This means that the microbes are unable to infect the body's cells, or alternatively, if the antigen is expressed at the surface of an infected cell, the immune system is stimulated to specifically destroy that cell.

    COVID-19: which monoclonal antibodies should be used for vulnerable

    pasteur.fr
    How are monoclonal antibodies produced?
    Monoclonal antibodies are obtained in the laboratory from a single lineage – a single clone, hence the adjective in their name – of immune cells, specifically B cells. Once the gene encoding the antibody of interest has been selected, it is inserted into "cell factories" to produce the monoclonal antibody at scale.

    COVID-19: which monoclonal antibodies should be used for vulnerable

    pasteur.fr
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  3. Nature
    https://www.nature.com/articles/s41586-024-07385-1

    Computationally restoring the potency of a clinical antibody …

  4. Allergy and Asthma Care of Los Angeles
    https://allergylosangeles.com/allergy-blog/cinqair-vs-nucala-vs...

    Cinqair vs. Nucala vs. Dupixent for Asthma - Los Angeles Allergist

  5. Medscape Education
    https://www.medscape.org/viewarticle/9…

    Evidence Update and Practical Perspectives: …

    WebMay 3, 2024 · The goal of this program is to provide clinicians with the latest information and expert perspectives on best the use of monoclonal antibody therapy in the care of patients with COVID-19. Upon …

  6. Nature
    https://www.nature.com/articles/s41568-024-00690-x

    Cancer therapy with antibodies | Nature Reviews Cancer

  7. Institut Pasteur
    https://www.pasteur.fr/en/research-journal/reports/covid-19-which...

    COVID-19: which monoclonal antibodies should be used for …

  8. Respiratory Therapy Zone
    https://www.respiratorytherapyzone.com/nonsteroidal-antiasthma-…

    Nonsteroidal Anti-Asthma Agents: Overview and Practice Questions

  9. Springer
    https://link.springer.com/article/10.1007/s10620-024-08413-w

    Efficacy and Safety of Monoclonal Antibodies for the Treatment of ...

  10. The New England Journal of Medicine
    https://www.nejm.org/doi/full/10.1056/NEJMoa2312775

    Subcutaneous Administration of a Monoclonal Antibody to …

  11. FactCheck.org
    https://www.factcheck.org/2024/04/scicheck-qampa-on-reducing-covi…

    Q&A on Reducing COVID-19 Risk for Elderly, Immunocompromised

  12. Medscape Education
    https://www.medscape.org/sites/advanc…

    Monoclonal Antibodies in COVID-19 Treatment and …

    Web2 days ago · Data suggest that neutralizing monoclonal antibodies (nAbs) play a key role in patient care because of their ability to neutralize SARS-CoV-2 in infected individuals with mild to moderate disease and to …