There are currently no effective interventions to counteract age-associated muscle decline.1,2 While a gradual decline in muscle mass and strength with aging is natural, environmental factors such as diet and exercise dictate the trajectory of the decline.3,4

Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint tissues, severe

Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a randomized, placebo-controlled trial in middle-aged adults where we administer a postbiotic compound